“Our approach is a little bit different than the regular antiviral approach where you directly target viral proteins,” says study senior author Jan E. Carette, a Stanford University microbiologist. Conventional therapies try to destroy viruses by targeting their proteins, which they need to live. But the pathogens need our proteins, too: they proliferate by injecting their DNA into host cells. Different viruses need different proteins to complete this process. Carette and his colleagues used CRISPR-Cas9 to screen the whole human genome, looking for a protein that all enteroviruses depend on to replicate....

The American Cancer Society just updated its recommendations from its last publication in 2012, and though the guidelines are similar there are some key takeaways. Much of it may sound like common sense: Eat a healthy diet, exercise plenty, and don’t drink alcohol. But research shows that the risk factors associated with being overweight, eating a poor diet, drinking significantly, and having a sedentary lifestyle account for 18.2 percent of all cancer cases in the US, and nearly 15....

If you’re looking for your next controller for gaming, you can start here. We found some of the best and more versatile PlayStation 4 controllers available right now. Like some kind of dispatch from a cyberpunk future, this Chengdao controller is stunning (especially in “Galaxy Purple”) for its aesthetic while also being a solid all around controller. If you’ve evolved beyond “square” and “triangle” buttons, you’ll appreciate that they’ve been replaced by some kind of cyber runes from the 31st century, and the smooth grip (made of sweat-proof material) feels amazing in your hand even after several hours of playing....

The two models feature the same impressive new EV technology. But first, let’s talk about how they sound. To replace the familiar roar of Bavarian pistons, the company turned to a different flavor of Teutonic music in the form of sounds created by famed film soundtrack composer, Hans Zimmer. BMW calls Zimmer’s creations “IconicSounds Electric.” Creating fake sound for drivers who are used to hearing something when they step on the “gas” sounds contrived, because it is....

The 22-year-old Brit watches this drama not through the visor of a helmet, but on the screen of a racing simulator. Baldwin is among the best esports drivers in the world, one of several dozen who earn a living competing in the digital domain. Now he’s preparing for his professional motor-sports debut on a bona fide road course. Baldwin earned his shot a few months earlier, when he won the second season of World’s Fastest Gamer, a reality television series that saw 10 would-be Mario Andrettis compete for the chance to go wheel-to-wheel with seasoned pros....

Here are a few of the nicest spice grinders currently on the market. Peugeot Olivier Roellinger 5.25 Inch Pepper Mill, Chocolate https://www.amazon.com/Peugeot-25601-Olivier-Roellinger-Chocolate/dp/B0027H4WI0/ref=sr_1_4?dchild=1&fst=as%3Aoff&keywords=spice+grinder&qid=1603052715&refinements=p_89%3APeugeot&rnid=2528832011&s=home-garden&sr=1-4 Caption: Bring some classic French elegance. Badge: Best for traditional design Markdown: This lovely French spice grinder was named after the famous 3 Michelin star restaurant awarded Chef Olivier Roellinger. The classic handsome design uses hand power to crush spices, turning clockwise for fine grinds or counterclockwise for coarse grinds....

Jordan, being of this planet, is bound by the same gravity as the rest of us, meaning the math behind his giant leap should be simple to deduce. He burst from the court with a vertical velocity of roughly 14.8 feet per second and stayed airborne for .92 seconds, reportedly as long as Mike Powell did during his record-holding long jump four years later. That was just enough time to reach the basket nearly 15 feet from where he took off....

Ever since Jim Jannard created the Red One, the company’s first 4K cinema camera, in 2007, it has become a go-to shooter for serious filmmakers. Up until then, HD cameras couldn’t match the resolution, dynamic range, and color of film. But the Red One could, and at a price of $17,500, it could do it for far less than the $200,000 HD units from Sony, Arri, and Panavision. Red cameras were used to film a multi­plex of blockbusters, like Spider-Man and The Hobbit....

Consider the styles Everyday bags are suitable for everything from commuting into work to darting about a college campus, and there are five main styles. Which one you pick is probably the most important decision you’ll have to make, and the easiest way to decide is to think about how you want to carry your belongings—there are awesome bags in each category. Backpacks “The ultimate urban bag,” according to Joseph Cunningham, lead designer of Peak Design’s soft goods and bags....

In a way, the report, with its gloomy proclamations on the end of the world as we know it, is peak 2018. Dramatic and desperate, it paints a picture that’s hard to envision: a world in which sea ice vanishes completely once every decade, coral reefs disappear entirely, and the world’s poorest and most vulnerable people bear the brunt of the climate disaster. But before you walk into the rising sea, take a deep breath and look at the surprising bright side....

Sony’s Walkman brand has a long, storied history. Heck, the company could have owned the MP3 player market if it weren’t for that pesky Steve Jobs. But now, if you want an MP3 player with high-quality sound that supports a wide range of audio files, Sony is the brand to check out. This model comes with 128GB of built-in storage as well as a Micro SD slot. Its advanced amplifier delivers hi-def sound in spades, and the device even features sound enhancement technology that can restore fidelity to compressed music files....

We’ve been looking at the global first-appearance question: why did modern science appear first in Western Europe as opposed to the empires of China, Islam, or India? But there’s another, more local, first-appearance question: why England as opposed to, say, France, Italy, or the Netherlands? The answer cannot be a monopoly on brilliant scientists. Scientists in nearly every nation across Western Europe contributed crucial scientific steps, as described earlier. Luck and timing always play a role in creativity and invention—the essence of a first-appearance story....

Yet despite its prevalence, few have studied the condition, which means a cure remains elusive. In this vacuum of answers, audiologist and hearing scientist Sarah Theodoroff guides patients on their quest for calm. She splits her time between treating vets and studying new techniques to quiet their inner clamor. Theodoroff got her earliest glimpse inside the human ear in a speech-language pathology class. “After seeing an eardrum for the first time, I was hooked,” she recalls....

Once all the new models have been unwrapped at EICMA and Intermot, it’s time to start looking forward to another year of testing, riding, and comparing. Right now, they’re all good motorcycles fresh off their press release blasts. But as the year unfolds, we’ll see which ones don’t live up to the hype, and which ones shine beyond their spec sheets. Of course, 10 models don’t cover everything for 2019, so drop your favorite in the comments....

In the wild, interbreeding is one of the ways plants remain genetically diverse. Domesticated crops don’t do this, so they have far less genetic diversity. If an illness can kill one of them, it likely can kill them all—so without diverse genes for disease resistance, domesticated plants like wheat and oats are vulnerable to contagion. As crops became domesticated, they also became genetically dissimilar from their wild relatives in ways that prevent the two from interbreeding....

When the researchers examined deceased whales, they identified a section of the soft palate that could shift to seal the upper airway while the whale feeds. The researchers, who dubbed the structure the ‘oral plug’ in the journal Current Biology on January 20, suspect that the plug also exists in other large baleen whales. Fin whales are found in oceans worldwide and can grow to 85 feet long. They belong to a group of large baleen whales called the rorqual family, along with several other sea giants including the blue whale and humpback whale....

Named the Siamraptor suwati, this particular dinosaur is a very primitive member of the Carcharodontosaurus family, a type of predator with knife-like teeth, found mostly around northern Africa about 100 million years ago. It’s also the first definitive theropod of its kind ever found in southeast Asia, the paper shows. Scientists from the Japan-Thailand Dinosaur Project discovered a set of Siamraptor bones in 2007, says study author Duangsuda Chokchaloemwong, a lecturer at Nakhon Ratchasima Rajabhat University in Thailand....

Güder, assistant professor in the department of bioengineering at Imperial College London, knows maybe he’s just been lucky. Like many consumers, he thinks about food safety, but tries to keep his perspective about the risks. “I do throw away items myself, but usually just use the ‘use-by’ dates as a reference point,” he said. “I do not solely rely on them.” He’s referring to the often baffling dates stamped on food labels, which, in reality, have little to do with safety — and pose little danger if ignored, except in the case of infant formula — according to the U....

Solid foams like these are made when the liquid in a gel is replaced with air. The structure is overall left the same, which leaves the resulting material mechanically strong but without any weight from water. Depending on what the fibers in the foam are made of, it could even be biocompatible or biodegradable. To make the lightweight gold foam, the researchers decided to use amyloid fibrils, proteins that usually dissolve into liquid (like milk) and are known to play a role in human biology (plaques of this material build up in the brains of people with Alzheimer’s, though no one is quite sure why)....

Yesterday, LinkNYC blessed the streets of Manhattan with free public Wi-Fi, opening four hotspots on Third Avenue. The Wi-Fi kiosks are replacing public pay phones, and according to Link’s website, the company plans to install more than 7,500 hotspots throughout the city over the next few years. To connect to Link’s public network, I just had to turn on my phone’s Wi-Fi and enter an email address when prompted. The website offers a vague promise of Wi-Fi “up to 100 times faster than average public Wi-Fi and your mobile device’s LTE network....